Paradigm Biopharmaceuticals Ltd
Paradigm Biopharmaceuticals Limited is a late-stage drug development company engaged in discovering, developing, and delivering pharmaceutical therapies.
The business
Paradigm Biopharmaceuticals Limited is a late-stage drug development company engaged in discovering, developing, and delivering pharmaceutical therapies. It is focused on the development of injectable pentosan polysulfate sodium (iPPS/PPS) for the treatment of osteoarthritis (OA) and mucopolysaccharidosis (MPS). PPS is a semi-synthetic drug manufactured from the wood chips of European beech trees. Extracted glucurono-xylans are sulfated to produce a negatively charged product that mimics glycosaminoglycans. It develops PPS under the brand name Zilosul. Other indications under investigation for PPS include the treatment of joint function, mobility, and pain in patients with mucopolysaccharidoses; treating alphavirus-induced arthralgia; chronic heart failure; acute respiratory distress syndrome; and allergic respiratory conditions. It is also advancing early formulation development for Pentacoxib, an oral combination of PPS and a COX-2 inhibitor targeting patients with earlier-stage OA.
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Latest news
Paradigm Biopharmaceuticals Completes Phase 3 Enrolment Ahead of September Interim Analysis
Paradigm Biopharmaceuticals completes Phase 3 PARA_OA_012 enrolment for Zilosul in knee OA; interim analysis in Aug 2026; top-line results Q1 2027.
Paradigm Biopharmaceuticals Publishes Canine Osteoarthritis Study Showing Durable PPS Benefits
Paradigm Biopharmaceuticals (ASX: PAR) reports durable 26-week canine OA PPS benefits in peer-reviewed PLOS One, bolstering translational human OA potential.
Paradigm’s iPPS shown to reduce cartilage loss and improve function in osteoarthritis patients
Late-stage drug development company Paradigm Biopharmaceuticals (ASX: PAR) has announced positive study data from a Phase 2 clinical trial of injectable pentosan polysulfate sodium (iPPS) for the treatment of acute pain associated with knee osteoarthritis. The study investigated changes in synovial fluid biomarkers with iPPS treatment compared with placebo in 61 participants administered with twice-weekly […]
Paradigm Biopharma’s knee osteoarthritis trial meets secondary endpoints, launches capital raise
Paradigm Biopharmaceuticals (ASX: PAR) has announced trial patients being treated with its injectable pentosan polysulfate sodium (iPPS) drug for osteoarthritis of the knee have confirmed improved knee function and pain reduction for six months. The biotechnology company today confirmed its phase 2b clinical trial has successfully met its key secondary endpoints of improved knee function […]
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